About us

SKILLS: Research and Development | Chemical Synthesis | Project Management | Team Management | Quantitative Research | Medical Research | Pharmaceutics | Process Operations | Resource Management.

KEY STRENGTHS: Industry Expertise: A seasoned professional with extensive expertise in the pharmaceutical industry, spanning over 10 years of industrial and 8 years of academic experience. Proficient in spearheading R&D operations, optimizing processes, and developing innovative pharmaceutical formulations.

Innovative Research and Development Leadership: Demonstrated ability to lead R&D initiatives. Proven track record in synthesizing biologically active compounds and pioneering novel drug candidates. Holds the credit of 3 patents and 15 National and International publications

Strategic Project Management: Skilled in developing and executing strategic project plans, ensuring timely delivery of results while adhering to budgetary constraints. Proficient in optimizing processes and resource allocation to enhance project efficiency.

Documentation and Reporting: Adept at maintaining documentation, including laboratory records, electronic data, and detailed reports. Well-versed in delivering high-quality documentation such as process packages, development reports, and validation results.

Process Optimization and Efficiency Enhancement: Expertise in optimizing process operations to maximize resource utilization and productivity while minimizing costs and expenses. Proven track record of developing formulation processes to achieve superior product quality and yield

EDUCATION:

TECHNICAL SKILLS:

WORK EXPERIENCE:

Research Scientist
Biehl Life Sciences
September 2024 - Present

Service Provider (Consultant)
SURAJ LABORATORIES PRIVATE LIMITED
R&D Centre, Kothuru Village & Mandal.
June 2024 - August 2024

Research Scientist
Chemazon Laboratory, Nacharam
2023 - May 2024

• Leading Innovative Research Initiatives: Spearheading cutting-edge research projects aimed at advancing process development, synthesis methodologies, and novel compound discovery within Chemazon Laboratories.
• Innovating Synthetic Processes: Leading the development of a synthetic process for 4-amino-2-mercaptophenol hydrochloride, contributing to the advancement of pharmaceutical synthesis methodologies.
• Scale-Up Synthesis: Successfully synthesized non-2-yn-1-ol compound in quantities up to 2 kilograms, demonstrating proficiency in large-scale synthesis techniques and ensuring consistent product quality.
• Process Development Expertise: Leading the synthesis and process development efforts for tert-butyl (S)-6-hydroxy-6-methyl-1,4-oxazepane-4- carboxylate, facilitating the expansion of the chemical library with potential pharmaceutical applications.
• Collaborating Across Disciplines: Collaborating with cross-functional teams to integrate diverse perspectives and expertise, fostering a culture of innovation and collaboration to tackle complex scientific challenges
• Optimizing Process Efficiency: Continuously evaluating and optimizing process efficiency to streamline operations, reduce costs, and accelerate project timelines, driving productivity and innovation.
• Identifying Emerging Opportunities: Proactively identifying emerging trends and opportunities in the pharmaceutical landscape, guiding strategic decision-making and investment in promising research areas.
• Establishing Strategic Partnerships: Cultivating strategic partnerships with academic institutions, industry collaborators, and research organizations to enhance Chemazon Laboratories' research capabilities and drive collaborative innovation.
• Worked on API-projects: 1. Febuxostat, 2. Vonoprazan Fumarate, 3. Cariprazine

Senior Lead Scientist
NACL Industries Limited in R&D Centre, Shadnagar
2021 - 2023

• Spearheaded Agrichem Projects: Led the synthesis initiatives for agrichemical compounds, including Azoxystrobin, Haloxyfop-(R)-Methyl, and Propyzamide, overseeing process research and development as well as impurity synthesis.
• Conducted Process R&D: Conducted extensive research and development activities to optimize synthesis processes, enhance product yields, and improve overall efficiency in agrichemical.
• Contributed to Cross-Functional Collaboration:Collaborated closely with interdisciplinary teams including chemists, engineers, and regulatory experts, facilitating seamless integration of project goals and objectives across departments for successful project execution.

Research Scientist-I
Keminntek Laboratories
2017 - 2020

• Conducted Process R&D Projects: Led Process R&D projects and cost reduction initiatives, contributing to the optimization of manufacturing processes and enhancing operational efficiency within KEMINNTEK LABORATORIES in Hyderabad, India.
• Synthesized Substituted Cathinone Compounds: Led projects focused on the synthesis of compounds belonging to the substituted cathinone class, demonstrating expertise in organic synthesis and medicinal chemistry.
• Executed Route of Synthesis (ROS):Developed and executed routes of synthesis (ROS), overseeing reactions and coordinating with chemists to ensure the smooth progress of projects on a day-to-day basis, facilitating the timely completion of objectives and milestones.

PAST EMPLOYMENT HISTORY:

DST (SERB) Fast Track Young Scientist
NATIONAL INSTITUTE OF TECHNOLOGY
Warangal, India (2014 - 2017)

• Synthesis of 4H-chromene-3,4-dicarboxylate derivatives via an isocyanide-based one-pot three component reaction
• Synthesis of benzo[a]anthracen-5-one, phenazine-8, 9-diol, pyrido[2,3-b]quinoxaline-7,8-diol and their derivatives

Associate Research Scientist
NEULAND LABORATORIES LIMITED
Hyderabad, India (2012 - 2014)

• Performed Process R&D-projects (CRAMS), done Ethacrynic acid synthesis in Kg scale API and Prepared Process Development Report (PDR).
• Success fully delivered Montelukast API-intermediate and prepared Feasibility report for Route-I and Route-II synthesis.

Research Scientist
SAPALA ORGANICS PVT. LTD.
Hyderabad, India (2011 - 2012)

• Done FTA-CRO-research work from Medicinal chemistry (from Japan)

Postdoctoral Research Associate
VIRGINIA COMMONWEALTH UNIVERSITY
Richmond, VA, US (2009 - 2011)

• Carried out research based on the development of novel medicinal agents with drug abuse and addiction application, based on our modelling studies.
• Deftly worked on a series of novel Naltrexamine derivatives are designed and synthesized.
• Administered Total synthesis of Anibamine core unit compounds: Total synthesis of Anibamine core unit library of compounds for chemokine receptor, CCR5 antagonist as novel anti-HIV agent and prostate cancer activity.
• Ascertained five step chemical syntheses of Tirofiban structural analogs as an anti-platelet molecule (anticoagulant), reductive amination with Dextran sulfate sodium salt as a key step reaction.

Postdoctoral Research Associate
SOUTHERN METHODIST UNIVERSITY
Dallas, TX, US (2007 - 2009)

• Monitored the design, synthesis, and biological active compounds like Neuroprotective agents: 47 compounds of 3-Substituted indolones have been synthesized and evaluated their biological activity.
• Skilfully developed:
  1. More than 100 compounds neuroprotective 3’-substituted indolin-2-one derivatives and 35 of 1, 4-Benzoxazine compounds as novel class of neuroprotective agents
  2. New method on “benzyne generated copper-catalyzed alkyne-aryne coupling” under microwave conditions

Postdoctoral Research Associate
UT-SOUTHWESTERN MEDICAL CENTER
Dallas, TX, US (2006 - 2007)

• Looked after the synthesis of:
  1. Eicosanoids analogues and pyrophosphates
  2. DDMS: DDMS (10, 10-Dibromo-N-(methylsulfonyl) dec-9-enamide) synthesized from commercially available Methyl oleate.
  3. Arachidonic acid derivatives: Synthesis of 14, 15-EET and 11, 12-EET

Research Scientist
SAI ADVANTIUM PHARMA LTD.
Hyderabad, India (2005 - 2006)

• Gained extensive exposure for drug intermediates basic R &D and Process R & D projects.
• Carried out multi step, medicinal chemistry synthesis of Drug intermediates with GMP standards: Synthesis of 1, 3, 5-triazine derivatives and glycosidation reaction on sugar derivatives, Metabasis and Supergen projects.
• Instrumentally scaled up-synthesis of halogenations reaction on p-toluene sulfonic acid

PATENTS, PUBLICATIONS, PRESENTATIONS & CONFERENCES

Patents

• 1, 4-Benzoxazine compounds and derivatives thereof as therapeutic drugs for the treatment of Neurodegenerative conditions. US-Patent No: US008680094B2, Date of Patent: March 25, 2014, Inventors: Santosh R. D'Mello, Dallas, TX (US); Edward R. Biehl, Dallas, TX (US); Haribabu Ankati, Dallas, TX (US); Shashidhar Kumar Akubathini, Karimnagar (INDIA).
• A process for preparation of Azoxystrobin. WO 2023/203574 A1, International filing date: April 19, 2023, Inventors: Bhoopal Meka, Venkat Reddy, S., Satyanarayana Goud, Chandra Sekhar Ande, Raja Malisetti, Shashidhar Kumar Akubathini, Singh, Sunil Kumar (INDIA).
• Simple process for preparation of Haloxyfop-(R)-Methyl ester. INDIA-Patent number: IN202241024144, Publication Date: 2023-10-27, Inventors: Meka, Bhoopal; Singh Sunil Kumar; Akubathini, Shashidhar Kumar; Ramesh, Kalmakala (INDIA).

Research Publications

• “Synthesis of 4H-chromene-3,4-dicarboxylate derivatives via an isocyanide-based one-pot three component reaction”. Akubathini Shashidhar Kumar, Vakiti Srinivas and Vedula Rajeswar Rao. Indian Journal of Chemistry, Section B: Organic and Medicinal Chemistry, 55B (11), 2016, 1420-1423.
• “Synthesis of benzo[a]anthracen-5-one, phenazine-8, 9-diol, pyrido[2,3-b]quinoxaline-7,8-diol and their derivatives”. Akubathini Shashidhar Kumar, Vakiti Srinivas and Vedula Rajeswar Rao. Indian Journal of Heterocyclic Chemistry. Vol 25, Number 3&4 (Jan-June 2016) 269-273.
• "Design, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3, 14β-dihydroxy-4, 5α-epoxy-6β-[(4’- pyridyl)carboxamido]morphinan Derivatives asPeripheral Selective Mu Opioid Receptor Agents". Yuan, Yunyun; Elbegdorj,Orgil;Chen, Jianyang; Akubathini, Shashidhar; Zhang, Feng; Stevens, David; Beletskaya, Irina; Scoggins, Krista; Zhang,Zhenxian; Gerk, Phillip; Selley, Dana; Akbarali, Hamid; Dewey, William; Zhang, Yan. Journal of Medicinal Chemistry.2012, 55(22), 10118-10129.
• “Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14b-dihydroxy- 4,5a-epoxy-6b-[(40- pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists”. Yunyun Yuan, Orgil Elbegdorj, Jianyang Chen, Shashidhar K. Akubathini, Irina O. Beletskaya, Dana E. Selley, Yan Zhang. Bioorganic & Medicinal Chemistry Letters 2011, 21, 5625-5629. 4
• “Identification of novel 1, 4- benzoxazine compounds those are protective in tissue culture and in vivo models ofneurodegeneration”. Lulu Wang, HaribabuAnkati, Shashidhar Kumar Akubathini, Michael Balderamos, Chelsey A. Storey, Anish V. Patel, Valerie Price, Doris Kretzschmar, Edward R. Biehl, Santosh R. D’Mello. Journal of Neuroscience Research.2010, 88(9), 1970-1984.
• Synthesis of 2-benzylidene and 2-Hetarylmethyl derivatives of 2H-1, 4-Benzoxazin-3-(4H)-ones as Neuroprotectingagents.Haribabu Ankati, Shashidhar Kumar Akubathini, Santosh R. D’Mello, Ed. R. Biehl. Synthetic Communications. 2010, 40 (16), 2364-2376.
• (E)-5-Bromo-3-(2, 6-dichlorobenzylidene) indolin-2-one. Hongming Zhang, Shashidhar Kumar Akubathini, Haribabu Ankati and Ed. Biehl. ActaCryst. 2009 E65, o2217
• The Copper-catalyzed alkyne-aryne coupling reaction under the microwave conditions: preparation of the Symmetric and the unsymmetric di-substituted alkynes. Shashidhar Kumar Akubathini, Ed. Biehl., Tetrahedron Letters. 2009, 50, 1809-1811.
• (Z)-3-(E)-3-Phenylallylidene) indolin-2-one. Hongming Zhang, Shashidhar Kumar Akubathini, Haribabu Ankati and Ed.Biehl. ActaCryst. 2009, E65, o363.
• (Z)-5-Fluoro-3-[(1H-pyrrol-2-yl) methylene]indolin-2-one. Hongming Zhang, Haribabu Ankati, Shashidhar Kumar Akubathini and Ed. Biehl. ActaCryst. 2009, E65, o8
• Synthesis and structure-activity relationship studies of 3’ substituted indolin-2-ones-as-effective-neuroprotective- agents. Balderamos M, Ankati H, Shashidhar Kumar Akubathini, Patel AV, Kamila S, Mukhergee C, Wang L, Biehl Ed. R, D’Mello S. R. Experimental Biology and Medicine. 2008, 233, 1395-1402.
• (E)-5- Chloro-3-(2, 6-dichlorobenzylidene) indolin-2-one. Hongming Zhang, Haribabu Ankati, Shashidhar Kumar Akubathini and Ed. Biehl. ActaCryst. 2008, E64, o2103.
• Synthesis of 3- Benzylidene, 5-Substituted 3-Benzylidene, 3-Hetarylmethylene and 5-Substituted Hetarylmethylene Derivatives of Indolin-2-ones. Haribabu Ankati, Shashidhar Kumar Akubathini, Sukanta Kamila, Chandrani Mukherjee, SantoshRaymond D’Mello and Edward R. Biehl. The Open Organic Chemistry Journal, 2008, 2, 138-147.
• Stereoselective synthesis of (-) – pestalotin. A. Shashidhar Kumar, Pushpal Bhaket and B. Venkateswara Rao. ARKIVOC 2005, (iii), 74-82. (Issue in Honor of Prof. A.V. Rama Rao).
• A versatile and efficient synthesis of (2S)-2-(hydroxymethyl)-N-Boc-2, 3-dihydro-4-pyridone. A. Shashidhar Kumar, B. Haritha and B. Venkateswara Rao. Tetrahedron Letters 2003, 44, 4261-4263.

Presentations & Conferences

• Deftly delivered the technical paper presentation at Emory University, Department of Pharmacology, Atlanta, Georgia, USA on February 18, 2011, for Research associate position
• Shashidhar Kumar Akubathini and Ed. R. Biehl, Copper-Catalyzed Alkyne-Aryne Coupling Reaction under Microwave Conditions, inclusive of: o Abstract, 64thSouthwest Regional Meeting of the American Chemical Society, Little Rock AR, USA on October 1-4 (2008) o SWRM-410, General Poster Session 3, Salon B and C (The Peabody Little Rock), USA.

Membership/Associations

• Active Member of Professional Associations: Engaged as a member of professional organizations including the American Chemical Society (ACS), Sigma-Xi (The Scientific Research Society), International Union of Pure and Applied Chemistry (IUPAC), and American Association of Pharmaceutical Scientists (AAPS).
• Experienced Journal Article Reviewer: Reviewed a total of 25 manuscripts for esteemed journals such as the Journal of Natural Products, Journal of Organic Chemistry, ARKIVOC, Organic Process Research & Development (OPRD), Tetrahedron Letters, Journal of Heterocyclic Chemistry (JHC), Chemistry of Heterocyclic Compounds, Medicinal Chemistry Research, and Journal of Combinatorial Chemistry (JCC), demonstrating a keen eye for detail and a commitment to maintaining the quality and integrity of scientific publications.

Fellowships

• DST (SERB) Fast Track Young Scientist, INDIA
• Postdoctoral Fellowship Awarded by National Institute on Drug Abuse (NIDA) and National Institute of Allergy and Infectious Diseases (NIAID), USA Post-doctoral Fellowship Awarded by Robert Welch Foundation, USA
• Senior Research Fellowship Awarded by Council of Scientific and Industrial Research (CSIR)-INDIA